Science, Volume 323, Issues 5917-5922American Association for the Advancement of Science, 2009 |
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Page 1509
... drug industry's downsizing and restructuring have been at play for some time . By Virginia Gewin O ut of the carnage come opportunities . Recent high profile drug failures - notably the withdrawals of the painkiller Vioxx and diabetes drug ...
... drug industry's downsizing and restructuring have been at play for some time . By Virginia Gewin O ut of the carnage come opportunities . Recent high profile drug failures - notably the withdrawals of the painkiller Vioxx and diabetes drug ...
Page 1720
... drug - binding pocket ( Fig . 3A and figs . S15 and S16 , and table S3 ) and are highly conserved ( fig . S1 ) , which suggests a common mechanism of poly - specific drug rec- ognition . For QZ59 - RRR and both QZ59 - SSS molecules ...
... drug - binding pocket ( Fig . 3A and figs . S15 and S16 , and table S3 ) and are highly conserved ( fig . S1 ) , which suggests a common mechanism of poly - specific drug rec- ognition . For QZ59 - RRR and both QZ59 - SSS molecules ...
Page 1721
... drug- binding pocket through an open portal . The residues in the drug- binding pocket ( cyan spheres ) in- teract with QZ59 compounds and verapamil in the inward - facing con- formation . ( B ) ATP ( yellow ) binds to the NBDs causing ...
... drug- binding pocket through an open portal . The residues in the drug- binding pocket ( cyan spheres ) in- teract with QZ59 compounds and verapamil in the inward - facing con- formation . ( B ) ATP ( yellow ) binds to the NBDs causing ...
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