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29960 | Acetanilid Comp. (Acetasal) (Daggett & Miller).

316.0 346.0 335.0 29212 Acetanilid Comp. No. 1 (Direct Sales Co.)..

358.01 423.5| 397.3 29238 | Acetanilid Tablets (Direct Sales) 343.0 366.0 356.9 29209 | Acetanilid Sodium Comp.

(Maltbie Chem. Co.)..... 382.0 404.0 391.0 29962 Acetanilid Tablets (Salcelol) (Stoddard Co.)..

338.0 364.0 353.0 29975 Acetanilid Tablets (Tilden Co.). 409.5 499.0 465.5 30208 Acetphenetidin (Direct Sales Co.).....

403.0) 432.0 416.0 29249 Acetphenetidin Tablets (TailbyNason)...

408.0 446.5 430.0 30220 Acetphenetidin Tablets (Mfr?).. 351.0 395.0 384.0 29959 Aspirin (Abbott Lab.)..

400.5 425.01 411.5 29234 Aspirin (A. D. S.).

338.5| 414.01 386.4 29929 Aspirin (A. D. S.).

371.0 432.0 399.7 29939 Aspirin (Bayer Co.)..

378.5 423.0 401.7 29930 Aspirin (Brewer & Co.)... 401.0 462.01 430.0 29240 Aspirin (Buffington, Inc.).. 387.5 406.0 398.0 29938 Aspirin (De Pill Co.).

375.0 399.5| 388.5 29237 Aspirin (Direct Sales Co.). 412.5 431.0 420.7 30207 Aspirin (Direct Sales Co.). 396.5| 417.0 406.7 30217 Aspirin (Drug Products Co.)... 387.0 423.0 401.6 29935 Aspirin (Fraser).

345.0 371.01 360.6 29906 Aspirin (Mfr?).

358.0 398.0 379.0 29941 | Aspirin (Harvey Co.).

403.01 421.0 409.0 29950 Aspirin (Harvey Co.).

378.0 389.6 382.5 29940 Aspirin (Lee & Osgood)

380.5 423.0 399.0 29933 Aspirin (Lehn & Fink).

381.5 412.5 401.4 29944 Aspirin (Mulford Co.)...

356.5 381.0 371.1 29218 Aspirin (National Drug Co.)... 396.0 407.0 403.0 29239 Aspirin (National Drug Co.)... 394.0 449.0 416.8 29928 Aspirin (Squibb)...

354.0 378.5| 362.8 29966 Aspirin (Surgeons and Physicians Supply Co.)..

403.5) 417.5| 410.5 29210 Aspirin (Tailby-Nason).

353.0 384.0365.4 29926 Aspirin (United Drug Co.).. 359.0 405.0 380.0 30202 Aspirin (The Upjohn Co.).. 460.0| 493.0 471.3 29945 Aspirin (Wyeth)..

356.0 390.0 380.0 29215 Aspirin (Yates D. & C. Co.)... 383.5 435.5 421.4 29901 | Aspirin (Yates D. & C. Co.)... 387.0466.0 431.1 29912 Aspirin (Yates D. & C. Co.)... | 443.01 470.5| 459.0 940 Blaud's Iron Pills (United Drug Co.)..

366.5 429.5| 397,0 30206 Calcium, Iodized (Direct Sales Co.)..

64.5 80.1 74.5 29229 Calcium Sulphide Pills (Upjohn Co.)....

136.0 152.0 143.0 29230 Calcidin (Abbott Laby.).. 124.3 139.91 130.9

38.5 44.0 24.5 75.5 61.0 44.5 61.0 18.5 24.5 18.5 20.5 36.0 26.0 40.0 18.0 11.6 42.5 31.0 24.5 11.0 55.0 24.5

9.0 11.5

6.0 19.5 15.3 11.1 14.2 4.6 6.3 4.4 5.0 9.0 7.2 10.6 4.4 3.0 10.7 7.7 6.6 2.7 13.2 6.8

14.0 31.0 46.0 33.0 34.0 52.0 79.0 27.5

3.4 8.5 12.1 7.0 8.9 12.3 18.3 6.0

63.0

15.9

15.6

20.9

16.0 15.6

11.2 11.9

TABLE XV. VARIATIONS IN WEIGHT OF TABLETS—Continued.

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6.5

10.3

3.1

9.3

12.1

17.0

4.3

3.6

3.0

17.4

12.7 7.3

15.1

29222

Calomel (Yates D. & C. Co.) 90.0 96.0 30223

92.3 6.0 29991 Calomel (Mfr?)..

114.0 126.5 121.0 12.5 29919 Corrosive Sublimate (Davis, Rose Co.)...

978.0 1009.0991.1 31.0 30227 Corrosive Sublimate (Davis, Rose Co.).

921.51011.0964.4 89.5 30228 Corrosive Sublimate (Morgenstern & Co.).

925.0 1045.0 993.0 120.0 29219 Coryza No. 2 (G. S. Stoddard & Co..)..

157.2 187.3 176.9 30.1 30209 Hexamethylenamine (Direct Sales Co.)..

317.01 331.01 323.6 14.0 29226 Hexamethylenetetramine (Buffington, Inc.)...

312.5 324.0 322.4 11.5 30212 Hex-Iodine Lozenges (Daggett & Miller)...

950.9 980.3 965.5 29.4 29908 Hydrastin Strychnine Trit.

(Smith Pharmacal Co.).. 75.3 89.4 80.9 14.1 29228 Migraine Tablets (Nat. Drug Co.)..

414.0 469.5| 435.5 55.5 29225 Migraine Tablets (Tailby-Nason) 220.0 236.5 226.0 16.5 29932 | Morphine Sulphate (Hypoderm.) (John Weyth & Bros.)..

15.5 18.0 16.6 2.5 29247 Nitroglycerine Tablets (Nat. Drug. Co.)..

34.9 40.0 37.5 5.1 29213 Phenolphthalein Tablets(Direct Sales Co.).

148.0 168.5) 162.9 20.5 29915 Quinine Sulphate (Harvey Co.). 230.0 270.5 253.5 40.5 29924 Quinine Sulphate (Standard Laby.).

245.5 261.0253.2 15.5 29246 Quinine Sulphate (Nat. Drug Co.)..

288.0 307.0 299.0 19.0 30203 Quinine Sulphate(Yates D. & C. Co.)

319.01 368.0 350.0 49.0 29910 Sedative Pills No. 3 (G. F. Harvey Co.).

390.8 499.3) 432.01 108.5 29953 Sodium Bromide (A. D. S.) 370.0 412.0 392.5 42.0 29978 Sodium Bromide (TailbyNason)....

640.0 658.0 650.0 18.0 29236 | Triple Bromides (Tailby-Nason) 495.5 516.5506.2 21.01 29961 Sodium Salicylate (Daggett & Miller)..

507.0 531.0 518.0 24.0 30214 Sodium Salicylate (Daggett & Miller)

397.01 419.0 406.7 22.0 29214 Sodium Salicylate (Direct Sales Co.).

416.0 448.5 436.0 32.5 29221 Sodium Salicylate (Direct Sales Co.)..

437.5| 470.0 454.2 32.5 29951 Sodium Salicylate (Harvey Co.). 320.0 413.01 373.3 93.0

13.6

12.6 16.0

6.1

6.4

14.0

25.1 10.7

2.8 4.1

4.6

5.4

7.5

7.2 24.9 TABLE XV. VARIATIONS IN WEIGHT OF TABLETS-Concluded.

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29208 Sodium Salicylate (Rheumatic

Tablets) (Maltbie Chem. Co.) 798.0 831.5 813.6 33.5 4.1 29931 Sodium Salicylate (Haberle Drug Co.)..

388.0 430.0 416.6 42.0 10.1 29923 Sodium Salicylate (Standard Laby.).

454.0 519.5485.8 65.5 13.5 29920 Sodium Salicylate (Strasenburg Co.)...

433.0 464.5| 452.7 31.5 7.0 29248 Sodium Salicylate (Syracuse Pharmacal Co.)..

381.0 404.0 392.1 23.0 5.9 29248D Duplicate of 29248 (Syracuse Pharmacal Co.).

380.0 398.0 390.0 18.0 4.6 29235 Sodium Salicylate Comp. (Tailby-Nason)..

398.5| 434.0 414.0 35.5 8.6 29903 Sodium Salicylate (TailbyNason.).

385.0 425.5| 412.7 40.5 9.8 29967 Sodium Salicylate (TailbyNason)

366.0 390.0 381.3 24.0 6.3 29946 Sodium Salicylate (Yates D. & C. Co.).

449.01 485.5 463.1 36.5 7.9 30211 Sodium Salicylate (Yates D. & C. Co.).

434.5! 486.5 455.3 52.0 11.4 29914 Strontium Salicylate (Daggett & Miller)..

500.0 535.0 509.0 35.01 6.9 29905 Strontium Salicylate (TailbyNason)..

425.0 457.0 441.0 32.0 7.3 29969 Strychnine Sulphate (A. D. S.). 165.0 188.0 178.1 23.0 12.9 29216 Strychnine Sulphate (Daggett & Miller Co.).

103.01 117.01 108.3 14.0 12.9 29216D Duplicate of 29216 (Daggett & Miller Co.).

103.5 114.5 111.0 11.0 9.9 29900 Strychnine Sulphate (Glen Pharmacal Co.).

73.0 85.5 78.7 12.5 15.9 30219 Strychnine Sulphate (The Harvey Co.)..

32.0 38.0 34.6

6.0 17.3 29211 Strychnine Sulphate (Nat. Drug Čo.)..

73.0 88.0 82.2 15.0 18.2 30210 Strychnine Sulphate (Yates D. & C. Co.)....

40.01 49.5 43.0 9.5

22.1 29916 Thyroid (Desiccated) Tablets (Harvey Co.).

396.5 547.5 496.2) 151.0 30.4 29989 Thyroid (Desiccated) Tablets (Harvey Co.).

366.0 512.0 409.2) 146.0) 35.7 29911 Valerian Compound. (Tailby. Nason)......

428.3) 460.4 446.1 32.1 7.2

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VARIATIONS IN MEDICAMENT. In addition to variations in medicament caused by the limitations of weight control, other factors enter into consideration, such as the purity of the basic drugs used, the mixing of them, and finally the limits of reasonable error in analysis. The manufacturer must be presumed to have determined that the drugs he uses conform to the limits of purity prescribed by the U. S. Pharmacopoeia or National Formulary, or, in case of drugs not recognized therein, to a degree of purity established by reliable analyses, and to have based the claims for his finished product accordingly. Approved analytical methods are available for many of the medicaments ordinarily encountered in products of this type; but conclusions must be drawn cautiously in case of methods, the limitations of which are not sufficiently established.

Table XVI gives maximum and average variations in medicament in terms of grains per tablet and in percentages referred, in both cases, to the quantities of drugs declared to be present. A study of the tabulation shows that the maximum variation from the dosage claimed has been a shortage in sixty-one items and an overage in forty items; in other words the--and +variations have been about 6:4. In more than one-half of the items determined, the variation in dosage between the lightest and heaviest tablets or pills was within 10 per cent. of the dosage declared; in over threefourths of the items this range was less than 15 per cent.; and in nearly seven-eighths of the items the range did not exceed 20 per cent.

If the average variation from claimed dosage is considered, the comparison is, naturally, somewhat better. Thus we find that the average variation from the stated dose is less than 10 per cent. in about four-fifths (79.8 per cent.), of the items determined; in about two-thirds (65.4 per cent.) of the items the variation does not exceed 5 per cent. These conclusions are best shown in tabular form as follows:

Maximum

Average variation

variation Per cent. Items Per cent. determined

determined 0 to 4.99 per cent..

24 23.8 68 65.4 5 to 9.99

31
30.7 15

14.4 10 to 14.99

24
23.7

8

7.7 15 to 19.99

8
7.9

5

4.8 20 to 29.99

11
10.9

6

5.8 30 upward

3* 3.0

2* 1.9 Totals..

101 100.0 104 100.0 *Includes one item (in 29960) which is obviously a mistake in labelling. Again we may refer to a similar summary? revised to a basis 1 Methods of the A. O. A. C. and of the U. S. Pharmacopoeia have been followed wherever possible.

2 Conn. Exp. Sta. Bull. 200 (1917).

Variations from

Items

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comparable with the above tabulation. The comparison as regards maximum variation from claim is as follows:

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Since an improvement has been shown in the matter of uniformity of weight of tablets as compared with our previous inspection, less variation in medicament would, therefore, be anticipated at this time. The above comparison shows that such is the case. About 55 per cent. of the determinations made were within 10 per cent. of the quantity of drug declared as compared with 45 per cent. showing a like range in 1917. Twenty-two per cent. of the individual items determined varied from the stated dose by 15 per cent. or more while the corresponding figures in our previous inspection is twenty-eight per cent. The improvement in uniformity of medicament parallels rather closely the increase in uniformity of tablet weights.

TABLE XVI. VARIATIONS IN MEDICAMENT IN TABLETS, ETC.
No.
Drug

Claim, Maximum variation, Average variation,
grains grains
per cent. grains

per cent. 29960 Acetanilid...

2.6 -0.4 -15.4 -0.2 -7.7 29975

5.0 +0.6 +12.0 +0.2 +4.0 29238

5.0 -0.4 -8.0 -0.2 -4.0 29209

2.5 +0.1 £4.0 +0.0 +0.0 29212

2.0 -0.3 - 15.0 -0.1 -5.0 29962

2.5 +0.1 +4.0 +0.0 +0.0 29228

2.5 -0.4 - 16.0 -0.3 - 12.0 29225

2.0 +0.1 +5.0 +0.0 +0.0 29235

2.5

+0.1 +4.0 +0.0 +0.0 29249 Acetphenetidin.... 5.0

$0.2
+4.0 +0.0

$0.0 30208

5.0

+0.6 +12.0 +0.3 +6.0 30220

5.0

-0.6 -12.0 -0.2 -4.0 29941 Aspirin.....

5.0 +0.3 +6.0 +0.1 +2.0 29950

5.0 +0.2 +4.0 +0.1 +2.0 29944

5.0 -0.3 -6.0 -0.1 -2.0 29940

5.0 +0.3 +6.0 +0.0 $0.0 29938

5.0 -0.3 -6.0 -0.1 -2,0 29939

5.0 -0.3 -6.0 +0.0 +0.0 29935

5.0

-0.7 -14.0 -0.5 - 10.0 29933

5.0 +0.3 +6.0 +0.1 +2.0 29930

5.0 -0.4 -8.0 +0.0 +0.0 29929

5.0 +0.7 -14.0 +0.2 +4.0 29234

5.0 -0.7 -14.0 -0.1 -2.0 29928

5.0 -0.3 - 6.0 -0.2 -4.0 29926

5.0 -0.6 -12.0 -0.3 -6.0

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