Science, Volume 313, Issues 5783-5788John Michels 2006 |
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Page 201
... nitrile of IDD743 ( green ) . ( C ) Chemical structure of IDD743 and closely related inhibitors , IDD393 and IDD594 , for which high - resolution structures are available ( 17 , 20 ) . Fig . 2. ( A ) Result of continuum electrostatics.
... nitrile of IDD743 ( green ) . ( C ) Chemical structure of IDD743 and closely related inhibitors , IDD393 and IDD594 , for which high - resolution structures are available ( 17 , 20 ) . Fig . 2. ( A ) Result of continuum electrostatics.
Page 202
... nitrile of IDD743 ( green ) . ( C ) Expanded view of slice in ( B ) in the vicinity of the nitrile probe . ( D ) Result of continuum electrostatics calculation , with the interior dielectric set to 4 , on the initial model of V47D HALR2 ...
... nitrile of IDD743 ( green ) . ( C ) Expanded view of slice in ( B ) in the vicinity of the nitrile probe . ( D ) Result of continuum electrostatics calculation , with the interior dielectric set to 4 , on the initial model of V47D HALR2 ...
Page 203
... nitrile bond of IDD743 , AF , for all mutants relative to wild - type : H110A ( 0 ) , Q49R ( □ ) , W20Y ( △ ) , F121E ( ) , Y48F ( ○ ) , V47D ( □ ) , K77M ( △ ) , and V47N ( ◇ ) . ( A ) AF calculated using initial structure models ...
... nitrile bond of IDD743 , AF , for all mutants relative to wild - type : H110A ( 0 ) , Q49R ( □ ) , W20Y ( △ ) , F121E ( ) , Y48F ( ○ ) , V47D ( □ ) , K77M ( △ ) , and V47N ( ◇ ) . ( A ) AF calculated using initial structure models ...
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EVOLUTION | 19 |
REPORTS | 23 |
Senate Prepares to Vote at Last on a Trio | 26 |
Copyright | |
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