Science, Volume 311, Issues 5763-5769John Michels (Journalist) 2006 |
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Page 1142
... NEMO ( also called IKKY ) . An- other important regulatory component of the IKK complex is a protein called ELKS ( 3 ) . Upon activation , IKK phosphorylates IκB to promote its ubiquitin - dependent degradation . Liberated NF - κB then ...
... NEMO ( also called IKKY ) . An- other important regulatory component of the IKK complex is a protein called ELKS ( 3 ) . Upon activation , IKK phosphorylates IκB to promote its ubiquitin - dependent degradation . Liberated NF - κB then ...
Page 1143
... NEMO is detectable in AT WT cells ( 721 and L40 ) but not in AT lymphoblast cells ( AT3LA and AT59 ) . ( E ) Coimmunoprecipitation of endog- enous NEMO with an antibody to ATM in HEK293 cells . ( F ) Coimmunopre- cipitation of ...
... NEMO is detectable in AT WT cells ( 721 and L40 ) but not in AT lymphoblast cells ( AT3LA and AT59 ) . ( E ) Coimmunoprecipitation of endog- enous NEMO with an antibody to ATM in HEK293 cells . ( F ) Coimmunopre- cipitation of ...
Page 1144
... NEMO- S85A after VP16 treatment occurred with com- parable kinetics to those of NEMO - WT but remained at the peak levels even 240 min after stimulation ( Fig . 4A ) . This nuclear export defect of NEMO - S85A was bypassed by ubiquitin ...
... NEMO- S85A after VP16 treatment occurred with com- parable kinetics to those of NEMO - WT but remained at the peak levels even 240 min after stimulation ( Fig . 4A ) . This nuclear export defect of NEMO - S85A was bypassed by ubiquitin ...
Contents
Revised Numbers Quicken the Pace of Rebound | 931 |
A Protein Farnesyltransferase Inhibitor Ameliorates Disease | 934 |
Report p 1005 | 937 |
Copyright | |
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