Science, Volume 317, Issues 5834-5840John Michels (Journalist) American Association for the Advancement of Science, 2007 |
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Page 239
... domain shows that oncogenic mutations in the adaptor - binding domain are not at the inter - SH2 interface but in a polar surface patch that is a plausible docking site for other domains in the holo p110 / p85 complex . We also examined ...
... domain shows that oncogenic mutations in the adaptor - binding domain are not at the inter - SH2 interface but in a polar surface patch that is a plausible docking site for other domains in the holo p110 / p85 complex . We also examined ...
Page 241
... domain and a basic residue on the surface of the nSH2 domain . We singly mutated each of the lysine or arginine residues on the surface of the nSH2 domain into glutamate . A 200 150 Relative PI3K activity ( % basal ) 50 100 50 0 p85ni ...
... domain and a basic residue on the surface of the nSH2 domain . We singly mutated each of the lysine or arginine residues on the surface of the nSH2 domain into glutamate . A 200 150 Relative PI3K activity ( % basal ) 50 100 50 0 p85ni ...
Page 366
... domain from another . To construct a single model that includes many PDZ domains , we developed a variation of a PSSM in which a peptide is predicted to bind to PDZ domain i if ❤i = Σ Ap.q0i.p.q > Ti P.q = ( 1 ) where is a binding ...
... domain from another . To construct a single model that includes many PDZ domains , we developed a variation of a PSSM in which a peptide is predicted to bind to PDZ domain i if ❤i = Σ Ap.q0i.p.q > Ti P.q = ( 1 ) where is a binding ...
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SCIENCE EXPRESS | 10 |
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