Science, Volume 296, Issues 5574-5577M. King, 2002 |
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Page 1886
... ( pVHL ) plays a central role in the cellular response to changes in oxygen availability . pVHL binds to HIF only when a conserved proline in HIF is hydroxylated , a modification that is oxygen - dependent . The 1.85 angstrom structure of ...
... ( pVHL ) plays a central role in the cellular response to changes in oxygen availability . pVHL binds to HIF only when a conserved proline in HIF is hydroxylated , a modification that is oxygen - dependent . The 1.85 angstrom structure of ...
Page 1887
... PVHL in an extended B strand - like conformation . ( A ) Schematic representation of the 15 - residue portion of the HIF - 1a destruction se- quence bound to the ẞ do- main of pVHL in the PVHL- ElonginB - ElonginC complex . The portion ...
... PVHL in an extended B strand - like conformation . ( A ) Schematic representation of the 15 - residue portion of the HIF - 1a destruction se- quence bound to the ẞ do- main of pVHL in the PVHL- ElonginB - ElonginC complex . The portion ...
Page 1888
... pVHL residues that interact with Hyps are highly conserved in the human , mouse , frog , fly , and worm pVHL orthologs ( Fig . 2B ) . Trp88 , Tyr98 , His115 , and Trp117 are among the 11 ẞ domain residues that are invariant in the five ...
... pVHL residues that interact with Hyps are highly conserved in the human , mouse , frog , fly , and worm pVHL orthologs ( Fig . 2B ) . Trp88 , Tyr98 , His115 , and Trp117 are among the 11 ẞ domain residues that are invariant in the five ...
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