that it has just sent in a first report to the Minister. I was acquainted with it here, and the following are in a few words the facts related in that first report on rabies. I had given to the commission nineteen vaccinated dogs in succession-that is to say, dogs which had been rendered refractory by preventive inoculations. Thirteen only of them had after their vaccination been already submitted to the test-inoculation on the brain.

The nineteen dogs were, for the sake of comparison, divided into sets along with nineteen more control dogs brought from the pound without any sort of selection. To begin with, two refractory dogs and two control dogs were on June 1 trephined and inoculated under the dura-mater, on the surface of the brain, with the bulb of a dog affected with ordinary street rabies.

On June 3 another refractory dog and another control dog were bitten by a furious street mad dog.

The same furious mad dog was on June 4 made to bite still another refractory and another control dog. On June 6 the furious dog which had been utilised on June 3 and 4 died. The bulb was taken out and inoculated, after trephining, into three refractory dogs and three control dogs. On June 10 another street mad dog, having been secured, was, by the commission, made to bite one refractory and one control dog. On June 16 the commission have two new dogs, a refractory one and a control one, bitten by one of the control dogs of June 1, which had been seized with rabies on June 14 in consequence of the inoculation after trephining which it had received on June 1.

On June 19 the commission got three refractory and three control dogs inoculated before their own eyes in the popliteal vein with the bulb of an ordinary street mad dog. On June 20 they have inoculated in their presence, and still in a vein, ten dogs altogether, six of them refractory and four just brought from the pound.

On June 28, the Commission hearing that M. Paul Simon, a veterinary surgeon, had a furious biting mad dog, have four of their dogs, two refractory and two control dogs, taken to his place and bitten by the mad dog.

The Rabies Commission have, therefore, experimented on thirtyeight dogs altogether-namely, nineteen refractory dogs and nineteen control dogs susceptible of taking the disease. Those of the dogs which have not died in consequence of the operations themselves are still under obscrvation, and will long continue to be. The commission, reporting

up to the present moment on their observations as to the state of the animals tried and tested by them, find that out of the nineteen control dogs six were bitten, of which six three have taken rabies. Seven received intra-venous inoculations, of which five have died of rabies. Five were trephined and inoculated on the brain; the five have died of rabies.

On the other hand, not one of the nineteen vaccinated dogs has taken rabies.

In the course of the experiments, on July 13, one of the refractory dogs died in consequence of a black diarrhoea which had begun in the first days of July. In order to ascertain whether rabies had anything to do with it as the cause of death, its bulb was at once inoculated, after trephining, into three rabbits and one guinea-pig. All four animals are still to-day in perfect health, a certain proof that the dog died of some common malady, and not of rabies.

The second report of the Commission will be concerned with the experiments made as to the refractoriness to rabies of twenty dogs to be vaccinated by the Commission themselves.

(M. Pasteur then announced that he had just received that same morning the first report addressed to M. Fallieres by the Official Commission on Rabies. It states that twenty-three refractory dogs were bitten by ordinary mad dogs, and that not one of them had taken rabies. On the other hand, within two months after the bites, 66 per cent. of the normal dogs similarly bitten had already taken the disease.)

November 1, 1886.-New Communication on Rabies.-On October 26, 1885, I acquainted the Academy with a method of prophylaxis of rabies after bites. Numerous applications on dogs had justified me in trying it on man. As early as March 1, 350 persons bitten by dogs undoubtedly mad, and several more by dogs simply suspected of rabies, had already been treated at my laboratory by Dr. Grancher. And in consideration of the happy results obtained it appeared to me that it had become necessary to found an establishment for anti-rabic vaccinations.

To-day, October 31, 1886, 2,490 persons have received the preventive inoculations in Paris alone. The treatment was in the first instance uniform for the great majority of the patients, notwithstanding the different conditions presented by them as to age, sex, the number of bites received, their seat, their depth, and the time which had elapsed

since the occurrence of the accident. It lasted ten days, the patient receiving every day an injection prepared from the spinal marrow of a rabbit, beginning with that of fourteen days' and ending with that of five days' desiccation.

Those 2,490 cases are subdivided according to nationality in the following manner:

The number of French persons has been considerable, amounting to 1,726, and it will be enough to confine ourselves, to the category. formed by them as a basis for discussing the degree of efficacy of the method.

Out of the total 1,726 cases treated, the treatment has failed ten times—namely, in the following cases:

The children: Lagut, Peytel, Clédière, Moulis, Astier, Videau.
The woman: Leduc, seventy years old.

The men

Marius Bouvier (thirty years), Clergot (thirty), and Norbert Magnevon (eighteen).

I leave out of count two other persons, Louise Pelletier and Moermann, whose deaths must be attributed to their tardy arrival at the laboratory, Louise Pelletier thirty-six days, and Moermann forty-three days after they had been bitten.

We have therefore ten deaths for 1,726 cases, or I in 170; such are, for France and Algeria, the results of the first year's application of the method.

Those statistics, taken as a whole, demonstrate the efficacy of the treatment, as proved further by the relatively large number of deaths. which occurred amongst bitten persons who had not been vaccinated.