Science, Volume 304John Michels (Journalist) Science Company, Moses King, 2004 A weekly record of scientific progress. |
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Page 293
... Calstabin2 - deficient mice ( calstabin2 - / - ) consistently exhibit exer- fecise - induced ventricular arrhythmias ( 6 ) . Ас- cordingly , restoring binding of calstabin2 to the RyR2 complex to prevent aberrant Ca2 + leakage from the ...
... Calstabin2 - deficient mice ( calstabin2 - / - ) consistently exhibit exer- fecise - induced ventricular arrhythmias ( 6 ) . Ас- cordingly , restoring binding of calstabin2 to the RyR2 complex to prevent aberrant Ca2 + leakage from the ...
Page 295
... calstabin2 affinity to RyR2 in calstabin2 +/- mice after exercise . ( A ) Equivalent amounts of RyR2 were immunoprecipitated with an antibody against RyR2 [ upper blot in ( A ) ] . Representative immuno- blots ( A ) and bar graphs ( B ) ...
... calstabin2 affinity to RyR2 in calstabin2 +/- mice after exercise . ( A ) Equivalent amounts of RyR2 were immunoprecipitated with an antibody against RyR2 [ upper blot in ( A ) ] . Representative immuno- blots ( A ) and bar graphs ( B ) ...
Page 296
... Calstabin2 4pA 500ms 4pA 50ms Calstabin2 Ρο 0.097 , Το 12.8 ms , Tc 29.6 ms -8 kDa C - Симитлик PKA + Calstabin2 + JTV519 C- 543210 543210 Events ( x1000 ) Events ( x1000 ) Events ( x1000 ) + F Po 0.004 , Το 5.1 ms , Tc 1150 ms B ...
... Calstabin2 4pA 500ms 4pA 50ms Calstabin2 Ρο 0.097 , Το 12.8 ms , Tc 29.6 ms -8 kDa C - Симитлик PKA + Calstabin2 + JTV519 C- 543210 543210 Events ( x1000 ) Events ( x1000 ) Events ( x1000 ) + F Po 0.004 , Το 5.1 ms , Tc 1150 ms B ...
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AAAS ABAD acid actin activity analysis applications areas associated atoms bacterial behavior binding Biol biology Ca² calmodulin calstabin2 Cancer candidate carbon cell biology Center channels Chem chromosome clinical complex curriculum vitae Department Descartes Prize Director drug E-mail electron enzymes experience function fusion fusion pore genes genetic genome human inactivation increase indicate Institute interaction Laboratory leptin luciferase magnetic Medical Medicine membrane ment mice mitochondrial molecular molecules mutant National Nature neurons Neurosci newspaper after newspaper north patch ob/ob observed ocean pathways peptide Ph.D Phys plastids POMC position POSTDOCTORAL ppbv protein proteomics receptor RyR2 sample says Science scientific scientists sequence signal Signal Transduction silicic acid siRNA Southern Ocean species structure studies SUMOylation surface synteny tankyrase target telomeres tetrapod tion ubiquitin Univ University vesicles wild-type