Science, Volume 304John Michels (Journalist) Science Company, Moses King, 2004 A weekly record of scientific progress. |
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Page 449
... ABAD and Aß within mitochondria ( 18 - nm gold particles for ABAD and 12 - nm gold parti- cles for Αβ ) . The two different sizes of gold particles are concentrated in the mito- chondria of brains from a patient with AD ( Fig . 1E ) and ...
... ABAD and Aß within mitochondria ( 18 - nm gold particles for ABAD and 12 - nm gold parti- cles for Αβ ) . The two different sizes of gold particles are concentrated in the mito- chondria of brains from a patient with AD ( Fig . 1E ) and ...
Page 450
... ABAD residues important for Aẞ binding : residues S98 to Y101 ( 10 ) and residues T108 to T110 . An ABAD mutant bearing Ser98 → Ala98 ( S98A ) , K99A , and Y101A mutations ex- hibited no specific interaction to Aß in a surface ...
... ABAD residues important for Aẞ binding : residues S98 to Y101 ( 10 ) and residues T108 to T110 . An ABAD mutant bearing Ser98 → Ala98 ( S98A ) , K99A , and Y101A mutations ex- hibited no specific interaction to Aß in a surface ...
Page 451
... ABAD - RP 201 ABAD 20- 15- 10- 10- Κ1 = 1.72 ± 0.20 μΜ 5 0 mutABAD 0 0 25 50 75 100 125 Αβ 40 , nΜ + + C nonTg Αβ + ABAD - DP + ABAD - RP + Cyto c Cyto c + + 1 2 3 ABAD peptides , log [ 10 " ] , nM Tg MAPP / ABAD Tg ABAD + + + + + E ...
... ABAD - RP 201 ABAD 20- 15- 10- 10- Κ1 = 1.72 ± 0.20 μΜ 5 0 mutABAD 0 0 25 50 75 100 125 Αβ 40 , nΜ + + C nonTg Αβ + ABAD - DP + ABAD - RP + Cyto c Cyto c + + 1 2 3 ABAD peptides , log [ 10 " ] , nM Tg MAPP / ABAD Tg ABAD + + + + + E ...
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AAAS ABAD acid actin activity analysis applications areas associated atoms bacterial behavior binding Biol biology Ca² calmodulin calstabin2 Cancer candidate carbon cell biology Center channels Chem chromosome clinical complex curriculum vitae Department Descartes Prize Director drug E-mail electron enzymes experience function fusion fusion pore genes genetic genome human inactivation increase indicate Institute interaction Laboratory leptin luciferase magnetic Medical Medicine membrane ment mice mitochondrial molecular molecules mutant National Nature neurons Neurosci newspaper after newspaper north patch ob/ob observed ocean pathways peptide Ph.D Phys plastids POMC position POSTDOCTORAL ppbv protein proteomics receptor RyR2 sample says Science scientific scientists sequence signal Signal Transduction silicic acid siRNA Southern Ocean species structure studies SUMOylation surface synteny tankyrase target telomeres tetrapod tion ubiquitin Univ University vesicles wild-type