Science, Volume 293John Michels (Journalist) American Association for the Advancement of Science, 2001 |
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Page 265
... parkin ( Fig . 1C , top panels ) in all three conditions . We conclude that in nor- mal human brain , parkin , an E3 Ub ligase , is part of a stable protein complex that includes a known E2 protein , UbcH7 , and a distinct aS isoform ...
... parkin ( Fig . 1C , top panels ) in all three conditions . We conclude that in nor- mal human brain , parkin , an E3 Ub ligase , is part of a stable protein complex that includes a known E2 protein , UbcH7 , and a distinct aS isoform ...
Page 266
... parkin's E2 binding partner , UbcH7 , at its COOH - termi- nal RING box . Therefore , we generated re- combinant myc - parkin Arg42 Pro42 ( R42P ) with the Arg to Pro mutation in the Ubl domain and recombinant myc - parkin Thr240 Arg240 ...
... parkin's E2 binding partner , UbcH7 , at its COOH - termi- nal RING box . Therefore , we generated re- combinant myc - parkin Arg42 Pro42 ( R42P ) with the Arg to Pro mutation in the Ubl domain and recombinant myc - parkin Thr240 Arg240 ...
Page 267
... Parkin's specificity for its substrate in human brain is demonstrated by the failure of E6 - AP , a non - PD related neural E3 ligase , to bind aSp22 , despite the shared ability of both ligases to recruit UbcH7 . Thus , the Ubl domain ...
... Parkin's specificity for its substrate in human brain is demonstrated by the failure of E6 - AP , a non - PD related neural E3 ligase , to bind aSp22 , despite the shared ability of both ligases to recruit UbcH7 . Thus , the Ubl domain ...
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