Stereochemistry of Organic Compounds: Principles and ApplicationsNew Age International, 1994 - 564 pages During Recent Years, Stereochemistry Has Undergone A Phenomenal Growth Both In Theory And Practice, With A Concomitant Increase Of Interest Among The Organic Chemists, Biological Chemists, Medicinal Chemists, And Pharmacologists. The Present Text Provides An Up-To-Date, Coherent; And Comprehensive Account Of The Subject Starting From The Fundamentals And Leading Up To The Latest Development As Far As Practicable. Emphasis Has Been Placed On Symmetry-Based Approach To Molecular Chirality, Stereochemical Terminologies (Modern Stereochemistry Is Replete, With Them), Topicity And Prostereoisomerism, Conformational Analysis, Dynamic Stereochemistry, Chiroptical Properties, And Assignment Of Absolute Configuration To Chiral Molecules.Dynamic Stereochemistry Has Been Discussed With Reference To Conformation-Reactivity Correlation, Stereoselective Syntheses, And Pericyclic Reactions. A Large Cross Section Of Organic Reactions With Stereochemical Implication Has Been Incorporated. Attempts Have Been Made To Familiarise The Readers With Modem Instrumental Techniques, Nuclear Magnetic Resonance In Particular, Used For Stereochemical Investigation. Each Chapter Is Provided With A Summary Which Highlights The Main Points Of The Text. Selective References, Mostly Of Textbooks, Monographs, Review Articles, And Significant Original Papers Have Been Given Extending Sometimes To Early 1991.The Book Is Expected To Fulfil The Long-Felt Need For A Comprehensive Text On Modern Organic Stereochemistry Which Is Conspicuously Absent Since The Publication Of Professor Eliels Book In 1962. The Text May Be Adopted At Any Stage Of The University Teaching And At The Same Time Be Useful To The Practising Organic Chemists. |
Contents
Foreword | 1 |
Chapter 2 | 15 |
Chapter 4 | 43 |
of symmetry | 57 |
Chapter 3 | 68 |
Topicity and Prostereoisomerism | 106 |
Racemisation and Methods of Resolution | 135 |
Determination of Configuration | 163 |
Monocyclic Compounds | 240 |
Constitutionally symmetrical chiral molecules | 279 |
References 71 | 303 |
Fused Ring | 306 |
Conformation and Reactivity | 339 |
Stereoselective Reactions | 404 |
Pericyclic Reactions | 446 |
Chapte Molecular Dissymmetry and Chiroptical Properties | 478 |
Conformations of Acyclic Molecules | 203 |
73 | 226 |
75 | 235 |
Chemical Stereochemical | 509 |
545 | |
Common terms and phrases
absolute configuration achiral acid acyclic addition alcohol Allinger Amer angle strain anti asymmetric synthesis asymmetric transformation atoms axial axis biphenyls bond angle C₂ carbon carbonyl CH2OH CH3 CH3 chair Chapter Chem chemical shifts chiral centre chiral molecules cis and trans cis isomer CO₂H compounds conformational analysis cyclic cyclohexane diastereomers diastereoselectivity diastereotopic dipole discussed double bond effect electron Eliel enantiomeric enantiomers enantioselective enantiotopic energy barrier enzyme equatorial equilibrium erythro Figure gauche interactions gives H H H H-bond homotopic hydrogen interconversion intramolecular ketones kinetic kJ mol known ligands meso method methyl mol¹ molecular molecules nomenclature nucleophile olefins optical rotation optically active orbital pair planar plane point group prochiral protons racemic racemisation reaction reagents rearrangement relative configuration respectively ring inversion rule shown solvent stable stereochemistry stereoisomers stereoselective steric structure substituents substrate symmetry synthesis temperature torsion angles trans isomer transition values îí ñîãí