Science, Volume 314, Issues 5796-5801John Michels (Journalist) American Association for the Advancement of Science, 2006 |
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Page 294
... phosphorylated FOX01 at serine - 249 ( Ser249 ) in vitro and in vivo . Phosphorylation of Ser249 resulted in cytoplasmic localization and inhibition of FOXO1 . This phosphorylation was abrogated upon DNA damage through the cell cycle ...
... phosphorylated FOX01 at serine - 249 ( Ser249 ) in vitro and in vivo . Phosphorylation of Ser249 resulted in cytoplasmic localization and inhibition of FOXO1 . This phosphorylation was abrogated upon DNA damage through the cell cycle ...
Page 296
... phosphorylation - resistant mutant S249A of FOXO1 ( Fig . 3 , C and D ) , suggesting that CDK2 - induced trafficking of FOXO1 from the nucleus to the cytoplasm may be mediated by phosphorylation at Ser249 Camptothecin is a DNA damaging ...
... phosphorylation - resistant mutant S249A of FOXO1 ( Fig . 3 , C and D ) , suggesting that CDK2 - induced trafficking of FOXO1 from the nucleus to the cytoplasm may be mediated by phosphorylation at Ser249 Camptothecin is a DNA damaging ...
Page 469
... phosphorylation and activation , ( ii ) the lack of S6 phosphorylation , and ( iii ) the de- creased phosphorylation of 4EBP1 , a known mTOR substrate . In contrast , the addition of SB203580 and U1026 , inhibitors of p38 and ...
... phosphorylation and activation , ( ii ) the lack of S6 phosphorylation , and ( iii ) the de- creased phosphorylation of 4EBP1 , a known mTOR substrate . In contrast , the addition of SB203580 and U1026 , inhibitors of p38 and ...
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