Science, Volume 314, Issues 5796-5801John Michels (Journalist) American Association for the Advancement of Science, 2006 |
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Page 294
... ( CDK2 ) is often abolished after DNA damage . The inhibition of CDK2 plays a central role in DNA damage - induced cell cycle arrest and DNA repair . However , whether CDK2 also influences the survival of cells under genotoxic stress is ...
... ( CDK2 ) is often abolished after DNA damage . The inhibition of CDK2 plays a central role in DNA damage - induced cell cycle arrest and DNA repair . However , whether CDK2 also influences the survival of cells under genotoxic stress is ...
Page 295
... CDK2 but not by catalytically inactive kinase - dead CDK2 - KD ( Fig . 3 , A and B ) . Notably , the effect of CDK2 was abrogated by treatment of cells with roscovitine , an inhibitor of CDK2 ( Fig . 3B ) . Mutations in FOXO1 ( S249A ...
... CDK2 but not by catalytically inactive kinase - dead CDK2 - KD ( Fig . 3 , A and B ) . Notably , the effect of CDK2 was abrogated by treatment of cells with roscovitine , an inhibitor of CDK2 ( Fig . 3B ) . Mutations in FOXO1 ( S249A ...
Page 296
... CDK2 - induced trafficking of FOXO1 from the nucleus to the cytoplasm may be mediated by phosphorylation at Ser249 ... CDK2 activity . Camptothecin treatment inhibited the activity of CDK2 in DU145 prostate cancer cells ( Fig . 4A ) ...
... CDK2 - induced trafficking of FOXO1 from the nucleus to the cytoplasm may be mediated by phosphorylation at Ser249 ... CDK2 activity . Camptothecin treatment inhibited the activity of CDK2 in DU145 prostate cancer cells ( Fig . 4A ) ...
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